| Prediction of Human Drug Metabolism: Regio- and Stereospecificity and P450 Substrate Contact Environment |
>> Full Text PDF
>> References |
|
* Department of Drug Metabolism and Molecular Toxicology, Faculty of Pharmaceutical Sciences, Tohoku University (Aramaki Aoba, Aoba-ku, Sendai 980, Japan) |
||
| Assessment of human drug metabolism is necessary for the evaluation of drug efficacy and safety. Studies on molecular cloning of drug metabolizing enzymes indicate the limited values of experimental animal data for the extrapolation to humans. Recent progress on the secondary structures of cytochrome P450 forms, however, provide an alternate predicting way through modeling of substrate contact environments of P450 forms. Usefulness of this approach is discussed with CYP2C P450 data. | ||
| Key words: Human drug metabolism, Cytochrome P450, Substrate specificity | ||
| [ Full Text PDF ] [ References ] |
| © COPYRIGHT by The Mass Spectrometry Society of Japan. All Rights Reserved. |