| Peptide and Protein Epitope Mapping by Mass Spectrometry |
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* Central Research Laboratories, Ajinomoto Co., Inc. (1-1 Suzuki-cho, Kawasaki-ku, Kawasaki-shi 210, Japan) |
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| Antigenic determinants, also called epitopes, constitute the region of the protein in intimate contact with the antigen-binding region of an antibody. Epitopes are typically classified as being either continuous or discontinuous. A variety of methods have been applied to the study of monoclonal antibody (mAb)-antigen interactions and the characterization of their respective epitopes. Here we introduce some new methods of peptide and protein epitope mapping by mass spectrometry. | ||
| Key words: Epitope mapping, Antibody, MALDI-TOF, Peptide, Protein | ||
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