| Why Is ESI More Suitable for the Observation of Multiply Charged Ions Than FAB? |
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* Faculty of Engineering, Yamanashi University (3-11 Takeda 4-chome, Kofu 400-8511, Japan) |
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| Comments on the mechanisms for the formation of multiply-charged ions from the electrosprayed charged liquid droplets were given. The excess charges in the charged droplets mainly locate on the surface of the droplets. Evaporation of solvent from the parent charged liquid droplets produced from the Taylor cone leads to uneven fission. The secondary droplets thus formed become much more highly-charged by the slip-over of the charged skin of the parent droplets. The excess charges donated in the secondary charged droplets result in the formation of highly charged gas-phase analyte ions through evaporation of the solvent and added acids or bases in the droplets. The ion formation by FAB is mainly due to the explosive evaporation of matrix element induced by the shock wave and thus the analyte ions observed generally represent those solvated in the matrix. This is why the number of excess charges in the analyte ions formed by FAB is smaller than those formed by electrospray. | ||
| Key words: Electrospray, FAB, Multiply-charged ion, Taylor cone | ||
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