JMSSJ On-line, Vol. 47 (1999) No. 3, pp. 149-159
Characteristics and Perspective of FT-ICR MS Applied to Biomolecular Characterization
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    Yasuhide NAITO*

    * The Institute of Physical and Chemical Research (RIKEN) (2-1 Hirosawa, Wako-shi 351-0198, Japan)

Fourier transform ion cyclotron resonance mass spectrometry (FT-ICR MS) is considered as one of the best option for biological application fields, where an extreme analytical performance in a very high mass region is increasingly demanded. This paper illustrates the characteristics of FT-ICR MS, involving the advantage and disadvantage, especially in being used for biological mass spectrometry. The contents include the origin of the ultra-high resolving power, the versatility of the ion trapping technique, and the congeniality to the advanced ionization methods for biomolecules.

Key words: Fourier transform ion cyclotron resonance mass spectrometry, Biomolecular characterization, Penning trap, Tandem-in-time, Low-energy collision-induced dissociation, Gas-phase ion chemistry

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