| Recent Progress of Combinatorial Chemistry |
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* Department of Chemistry, Graduate School of Science, Osaka University (Machikaneyama 1-1, Toyonaka 560-0043, Japan) |
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| This review describes the recent progress of combinatorial chemistry for drug discovery. Application of combinatorial chemistry is also described to functional studies of biologically active natural products including our studies of bacterial glycoconjugate lipid A. Lipid A analogs were synthesized via a new divergent synthetic route in order to clarify the biological importance of acyl groups. The number and chain length of the fatty acyl groups proved to have crucial influence on the biological activity. The present divergent route opens an efficient way toward the synthesis of lipid A libraries. | ||
| Key words: Combinatorial chemistry, Solid-phase synthesis, Encoded combinatorial library, Deconvolution, SH3 ligand, Somatostatin, Aspartyl protease inhibitor, β-Turn mimetic, Lipid A, CDK inhibitor, Divergent synthesis | ||
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