JMSSJ On-line

JMSSJ On-line, Vol. 47 (1999) No. 6, pp. 386-388

*An Application of the On-line Respiratory Mass Spectrometer to the Detection of Helicobacter pylori* Infection Using ¹³C-Labeled Urea**		>> Full Text PDF >> References
*Jun FUTAMI^a), Hiroaki IRIE^b), Shuzo OHE^c), and Isao NISHI^b)** ^a) Department of Economic Informatics, Faculty of Economics, Higashi Nippon International University (37 Suganezawa, Kamata, Taira, Iwaki, Fukushima 970-8567, Japan)* ^b) Department of Electronics and Computer, Faculty of Science and Engineering, Science University of Tokyo in Yamaguchi (1-1-1 Daigakudori, Onoda, Yamaguchi 756-0884, Japan) ^c) Department of Industrial Chemistry, Graduate School of Engineering, Science University of Tokyo (1-3 Kagurazaka, Shinjuku-ku, Tokyo 162-8601, Japan)

In recent studies, it has been revealed that Helicobacter pylori (HP) causes stomach cancer, stomach ulcers, duodenal ulcers and chronic gastritis. The ¹³C-urea breath test (UBT) is one of the diagnostic methods for HP infection. A new UBT method with the respiratory mass spectrometer developed by authors continuously measures with on-line the amount of decomposed ¹³C-urea in the stomach after the administration of ¹³C-urea. Trial examinations by the new method were carried out with two subjects; one was diagnosed positive of HP infection and the other was negative by clinical examinations. Significant difference was found in the amount of decomposed ¹³C-urea between both subjects. The results presented in this paper demonstrate that the new UBT method is applicable to the clinical use in the diagnosis of HP infection.

Key words: Urea breath test, Carbon thirteen, Mass spectrometer, Helicobacter pylori

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