JMSSJ On-line, Vol. 48 (2000) No. 1, pp. 23-25

Intercharge Distances in Zn7-Metallothionein Analyzed by Nanospray on a Quadrupole Ion Trap and Molecular Modeling		>> Full Text PDF >> References
Catherine FENSELAU,*a), †† Zoltán SZILÁGYI,a) and Tracie WILLIAMSa) † This paper is dedicated to the late Professor Akira TATEMATSU. †† Financial support was provided by the National Institutes of Health (Grant #21248). a) Department of Chemistry/Biochemistry, University of Maryland (College Park, MD 20742-2021, U.S.A.)
A narrow charge state distribution is observed for Zn7-metallothionein ionized by electrospray and nanospray ionization in solutions that conserve its native structure. Based on the structure determined by X-ray crystallography, average intercharge distances are calculated, which are consistent with earlier models for geometric distribution and with direct measurements of intercharge distances on a polypeptide.
Key words: Metallothionein, Electrospray ionization, Nanospray ionization, Ion trap mass spectrometry, Charge state

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