JMSSJ On-line

JMSSJ On-line, Vol. 51 (2003) No. 1, pp. 146-152

Strategy against Infections of Virions and Bovine Spongiform Encephalopahty (BSE) Prion		>> Full Text PDF >> References
Sei-ichi MANABE^* ^Faculty of Human Environmental Science, Fukuoka Women's University (1-1-1 Kasumigaoka, Higashi-ku, Fukuoka 813-8529, Japan)*

The prion proteins and virions were introduced as typical causative agents of BSE and epidemic virus disease such as AIDS. The process validation on confirmation of removal and/or inactivation of these agents at the purification step in bio-drug manufacturing process was described briefly and this validation is the most effective strategy against the fear of the infections. The mass spectrometry about the infectious agents might give fruitful contribution to the development of the virus removal filter developed recently in order to complete the process varidation.

Key words: Virus, Prion, Process validation, Bio-drug, Filter