JMSSJ On-line, Vol. 52 (2004) No. 1, pp. 33-38
Recent Developments in Soft Laser Desorption/Ionization Mass Spectrometry
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    Ryuichi ARAKAWAa),*b), Shoji OKUNOa), and Yoshinao WADAa),c)

    a)Japan Science and Technology Agency, Wada Proteomics Project (3-1-10 Technostage, Izumi, Osaka 594-1144, Japan),*b)Department of Applied Chemistry, Kansai University (3-3- 35 Yamatecho, Suita, Osaka 564-8680, Japan),c)Osaka Medical Center and Research Institute for Material and Child Health (840 Murodo-cho, Izumi, Osaka 594-1101, Japan)
The soft laser desorption/ionization represented by matrix-assisted laser desorption/ionization is currently an indispensable method of analyzing a wide variety of compounds including biopolymers, synthetic polymers, endocrine disruptors, and metal complexes. In order to make the best of its potentials, a number of related techniques have been developed, being focused on sample preparation, matrix usage, sample targets, and mass analyzers. This review collects noticeable advances in these topics to suggest the directions of further investigation.
Key words: Laser desorption/ionization(LDI),Matrix-assisted laser desorption/ionization (MALDI), Sample preparation, Desorption/ionization on porous silicon (DIOS), Atmospheric pressure (AP)-MALDI, IR-MALDI, Ion mobility spectrometry
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