| Toward Functional Proteomics from the Science of Complexity: Paradigm Shift from Reductionism |
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First Department of Surgery, Tokyo Medical University, Shinjuku-ku, TOKYO, JAPAN |
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| The results of recent worldwide activities undertaken to discover biomarkers of diseases suggest that huge numbers of promising biomarkers will soon be identified because of advances in quantitative proteomic platforms such as multiple-reaction monitoring mass spectrometry. These newly identified biomarkers will aid in the understanding of biology and other life sciences. The science of reductionism has aided in the understanding of the physical sciences; however, it is questionable whether reductionism is useful in understanding life sciences. The science of complexity has recently attracted the attention of scientists and has proven successful in areas such as economics, sociology, and so on. The author has therefore attempted to discuss the potential usefulness of the science of complexity in understanding life sciences and life itself. | ||
| Key words: Protein biomarker, Science of complexity, Functional proteomics, Quantitative proteomics, Verification and validation | ||
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